DOI
https://doi.org/10.47689/2181-1415-vol5-iss9/S-pp92-98Kalit so‘zlar
hayot sifati , WHOQOL-BREFis. BNDF , gemodializAnnotasiya
Ushbu tadqiqot hayot sifatini baholash vositasi bo'lgan WHOQOL-BREF so'rovnomasining ahamiyatini va surunkali buyrak kasalligi (CKD) bilan asoratlangan 2-toifa qandli diabet (T2DM) bilan og'rigan bemorlarda miyadan olingan neyrotrofik omil (BDNF) biomarkerining ahamiyatini baholashga qaratilgan. ) gemodializ olayotganlar. 2019-yil 1-yanvardan 2020-yil 31-dekabrgacha dasturlashtirilgan gemodializdan o‘tayotgan T2DM va III bosqich surunkali buyrak etishmovchiligi (CRF) bo‘lgan jami 90 nafar bemor tekshirildi. Bu bemorlar surunkali miya yarim ishemiyasi (SCI) og‘irligiga qarab uch guruhga bo‘lingan. ). Natijalar shuni ko'rsatdiki, CCI darajasi oshgani sayin, qon zardobida BDNF darajasi nazorat guruhiga nisbatan sezilarli darajada kamaydi. Bundan tashqari, WHOQOL-BREF ko'rsatkichlari va turli klinik, laboratoriya va instrumental ko'rsatkichlar, shu jumladan kasallikning davomiyligi, ochlikdagi glyukoza, glyukozalangan gemoglobin darajasi, BDNF va karotid va vertebral arteriyalarda qon oqimi tezligi o'rtasida sezilarli bog'liqlik aniqlandi. Tadqiqot WHOQOL-BREF so'rovining ushbu bemor populyatsiyasining hayot sifatini baholashda muhimligini ta'kidlaydi va BDNFni gemodializdan o'tayotgan T2DM bemorlarida miya ishemiyasi uchun qimmatli marker sifatida aniqlaydi.
Ko'chirildi
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