Etiological aspects of viral encephalitis explored using PCR-based cerebrospinal fluid analysis, considering patients’ HIV status

Janna  Nazarova; Munisa  Bakhadirova; Dilbar  Khidoyatova; Malika Dushaeva

doi:10.47689/2181-1415-vol4-iss3-pp92-99

Janna Nazarova Center for the Development of Professional Skills of Medical Personnel
Munisa Bakhadirova Center for the Development of Professional Skills of Medical Personnel
Dilbar Khidoyatova Republican Scientific Center for Emergency Medical Care
Malika Dushaeva Republican Scientific Center for Emergency Medical Care

DOI

https://doi.org/10.47689/2181-1415-vol4-iss3-pp92-99

Keywords

HIV , viral encephalitis , PCR , cerebrospinal fluid

Abstract

This study examined 124 patients suffering from acute viral encephalitis who were admitted to the Center for the Development of Professional Skills of Medical Personnel between 2014 and 2019. The research focused on the outcomes of cerebrospinal fluid PCR diagnostics in viral encephalitis cases, taking into account patients' HIV status. Findings revealed that PCR testing offers a more reliable diagnosis and, when lab resources permit, should be employed for CSF analysis to more accurately identify the etiological agent responsible for SVE. It is advised to repeat real-time PCR diagnostics of CSF in cases where the cause of SVE remains undetermined to improve detection rates of SVE's causative factors and enhance targeted therapy effectiveness, shifting from empirical and symptomatic to etiotropic approaches.

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References

Rukovodstvo po infeksionnim boleznyam. [Handbook of Infectious Diseases. In 2 vols. 2 / ed. by Acad. V. Lobzin, Prof. K.V. Zhdanov. - 4-th edition, updated and revised. - Saint-Petersburg: Publishing House Foliant, 2011. - 744 p.]

Ensefaliti v klinicheskoy praktike – tak li vse prosto? // Klinicheskaya mikrobiologiya i antimikrobnaya ximioterapiya [Karpov I.A., Kachanko E.F., Vasilenko A.I., Y.L. et al. Encephalitis in clinical practice - is it that simple? // Clinical Microbiology and Antimicrobial Chemotherapy, 2011, Vol. 13, No. 2, pp.104-133.]

Obshaya nevrologiya. [Nikiforov A.S., Gusev E.I. General neurology. - Moscow: GEOTAR-Media. 2013.]

Sovremenniye aspekti rasprostranennosti i etiologii razvitiya virusnix ensefalitov // Sovremenniye problemi nauki i obrazovaniya. [Reveguk E.A., Karpov S.M., Zavodnova O.S. Modern aspects of prevalence and etiology of viral encephalitis // Modern problems of science and education. - 2018. - № 4. - P.249-254.]

Molecular Virology / S. Modrow, D. Falke, U. Truyen, H. Schätzl. – B. etc.: Springer, 2013. – 1013 p.

Spatola M, Du Pasquier RA. Immune system's role in viral encephalitis. Rev Neurol (Paris). 2014; 170:577–83.

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Published

2023-06-10

Etiological aspects of viral encephalitis explored using PCR-based cerebrospinal fluid analysis, considering patients’ HIV status

How to Cite

Nazarova, J. ., Bakhadirova, M. ., Khidoyatova , D. ., & Dushaeva , M. (2023). Etiological aspects of viral encephalitis explored using PCR-based cerebrospinal fluid analysis, considering patients’ HIV status. Society and Innovation, 4(3), 92–99. https://doi.org/10.47689/2181-1415-vol4-iss3-pp92-99