DOI
https://doi.org/10.47689/2181-1415-vol5-iss2-pp151-156Keywords
interleukins , HIV , CD4 cellsAbstract
This article describes the results of the study and the characteristics of the cytokines IL-4, IL-18, IFN-γ and TNF-α in the blood plasma of HIV-positive and HIV-negative children. The study design was a cross-sectional study in which blood samples were collected from study subjects during ART. Cytokines IL-4, IL-18, TNF-α and INF-γ were determined using an ELISA kit (Vector Best, Russian Federation). The results showed the concentration of IFN-gamma, a regulator of the humoral immune response, in the group of patients with HIV infection was statistically significantly higher than in the control group (p=0.00001). On the contrary, the concentration of another regulator of the humoral immune response, IL-4, differs slightly in the main and control groups (p = 0.1425). The content of the pro-inflammatory cytokine TNF-alpha in the HIV-positive group was significantly higher than in the HIV-negative group (p = 0.00001). Also, the concentration of the pro-inflammatory cytokine IL-18 was significantly higher in the main group than in the control group (p=0.0002). Although cytokine profiles during antiretroviral therapy among people living with HIV (PLHIV) have been documented, no clearly defined pattern of effects of antiretroviral therapy on cytokine profiles has been identified.
Downloads
References
Tudela, E. V., Singh, M. K., Lagman, M., Ly, J., Patel, N., Ochoa, C., & Venketaraman, V. (2014). Cytokine Levels in Plasma Samples of Individuals with HIV Infection. Austin Journal of Clinical Immunology, 1(1), 1003–1007. https://austinpublishinggroup.com/clinical-immunology/fulltext/ajci-v1-id1003.pdf
da Cunha, J., Maselli, L. M. F., Stern, A. C. B., Spada, C., & Bydlowski, S. P. (2015). Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs. World Journal of Virology, 4(2), 56–77. https://doi.org/10.5501/wjv.v4.i2.56
Osuji, F. N., Onyenekwe, C. C., Ahaneku, J. E., & Ukibe, N. R. (2018). The effects of highly active antiretroviral therapy on the serum levels of pro-inflammatory and anti-inflammatory cytokines in HIV infected subjects. Journal of Biomedical Science, 25(1), 1–8. https://doi.org/10.1186/s12929-018-0490-9
Fantauzzi, A., Floridia, M., Falasca, F., Spanedda, P., Turriziani, O., Vullo, V., & Mezzaroma, I. (2015). Backbone switch to abacavir/lamivudine fixed-dose combination: Implications for antiretroviral therapy optimization". New Microbiologica, 38(4), 531–540. https://www.newmicrobiologica.org/PUB/allegati_pdf/2015/4/531.pdf
Amoani, B., Sakyi, S. A., Amoah, P., Pomeyie, K., Aniagyei, W., Opoku, S., Sewor, C., & Saahene, R. O. (2021). Effect of ART on Cytokine Profile amongst HIV Patients : A Systematic Review and Meta-Analysis. Focus on Medical Sciences Journal, 7(3).
JR, W., & NG, K. (2016). Immunological Profiles in HIV Positive Patients with or without Opportunistic Infections and the Influence of Highly Active Antiretroviral Therapy: A Systematic Review and Update. Journal of Clinical & Cellular Immunology, 7(3). https://doi.org/10.4172/2155-9899.1000429
Akase, I. E., Musa, B. O. P., Obiako, R. O., Ahmad Elfulatiy, A., & Mohammed, A. A. (2017). Immune Dysfunction in HIV: A Possible Role for Pro- and Anti-Inflammatory Cytokines in HIV Staging. Journal of Immunology Research, 2017. https://doi.org/10.1155/2017/4128398
Amoani, B., Sakyi, S. A., Barnie, P. A., & Pomeyie, K. (2021). Effect of ART on Cytokine Profile amongst HIV Patients: A Systematic Review and Meta-Analysis Infection and Immunity View project Immune responses to hookworm infection View project. August. https://www.researchgate.net/publication/358266364
Bastard, J.-P., Soulié, C., Fellahi, S., Haïm-Boukobza, S., Simon, A., Katlama, C., Calvez, V., Marcelin, A.-G., & Capeau, J. (2012). Circulating interleukin-6 levels correlate with residual HIV viraemia and markers of immune dysfunction in treatment-controlled HIV-infected patients. Antiviral Therapy, 17(5), 915–919. https://doi.org/10.3851/IMP2093
Brites-Alves, C., Luz, E., Netto, E. M., Ferreira, T., Diaz, R. S., Pedroso, C., Page, K., & Brites, C. (2018). Immune activation, proinflammatory cytokines, and conventional risks for cardiovascular disease in HIV patients: A case-control study in Bahia, Brazil. Frontiers in Immunology, 9(JUN), 0–5. https://doi.org/10.3389/fimmu.2018.01469
Campillo-Gimenez, L., Casulli, S., Dudoit, Y., Seang, S., Carcelain, G., Lambert-Niclot, S., Appay, V., Autran, B., Tubiana, R., & Elbim, C. (2014). Neutrophils in antiretroviral therapy-controlled HIV demonstrate hyperactivation associated with a specific IL-17/IL-22 environment. The Journal of Allergy and Clinical Immunology, 134(5), 1142-52.e5. https://doi.org/10.1016/j.jaci.2014.05.040
Connolly, N. C., Riddler, S. A., & Rinaldo, C. R. (2005). Proinflammatory cytokines in HIV disease - A review and rationale for new therapeutic approaches. In AIDS Reviews (Vol. 7, Issue 3).
Downloads
63 23Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Дониёр Каримов, Зульфия Ахмеджанова, Дильбар Урунова, Ботир Эрматов, Баходир Эргашев, Ойбек Меликузиев, Нигора Суннатова, Шовкат Азимов (Автор)
This work is licensed under a Creative Commons Attribution 4.0 International License.
