The association between high hemoglobin levels and pregnancy complications, gestational diabetes and hypertension

Zukhra Bektemirova

doi:10.47689/2181-3663-vol1-iss1-pp64-71

Zukhra Bektemirova Student, Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan

DOI

https://doi.org/10.47689/2181-3663-vol1-iss1-pp64-71

Keywords

maternal mortality , maternal morbidity , fasting blood sugar , high hemoglobin level , gestational hypertension , gestational diabetes

Abstract

Gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) are the principal causes of maternal morbidity and mortality. The maternal morbidity and mortality burden for women is relatively high, suggesting a substandard quality of care. Therefore, an early diagnosis of GDM and gestational hypertension (GH) can improve prenatal care for pregnant women and improve pregnancy outcomes. Previous studies demonstrated that elevated Hb levels in the first trimester indicate possible pregnancy complications and should not only be considered as good iron status. However, ethnic differences could play a role in determining the magnitude of the association. We hypothesized that high Hb levels (≥12.5 g/dl) in the first trimester (6-13 gestational weeks, GW) are associated with an increased risk of fasting blood sugar (FBS) ≥126 mg/dl, systolic blood pressure (SBP) ≥140 mmHg, and diastolic blood pressure (DBP) ≥90 mmHg among pregnant women visiting prenatal clinics.

References

Preeclampsia, gestational diabetes and later risk of cardiovascular disease: women's experiences and motivation for lifestyle changes explored in focus group interviews. Sandsæter HL, Horn J, Rich-Edwards JW, Haugdahl HS. BMC Pregnancy Childbirth. 2019;19:448. [PMC free article] [PubMed] [Google Scholar]

Pancreatic disorders of pregnancy. Diagnosis, management, and outcome of gestational diabetes. Bevier WC, Jovanovic-Peterson L, Peterson CM. https://pubmed.ncbi.nlm.nih.gov/7781621/#article-details. Endocrinol Metab Clin North Am. 1995;24:103–138. [PubMed] [Google Scholar]

Longitudinal changes in insulin release and insulin resistance in nonobese pregnant women. Catalano PM, Tyzbir ED, Roman NM, Amini SB, Sims EA. Am J Obstet Gynecol. 1991;165:1667–1672. [PubMed] [Google Scholar]

Severe pre-eclampsia and hypertensive crises. Arulkumaran N, Lightstone L. Best Pract Res Clin Obstet Gynaecol. 2013;27:877–884. [PubMed] [Google Scholar]

Hypertensive disease of pregnancy and maternal mortality. Lo JO, Mission JF, Caughey AB. Curr Opin Obstet Gynecol. 2013;25:124–132. [PubMed] [Google Scholar]

Diabetes care in refugee camps: the experience of UNRWA. Shahin Y, Kapur A, Seita A. Diabetes Res Clin Pract. 2015;108:1–6. [PubMed] [Google Scholar]

Increasing neonatal mortality among Palestine refugees in the Gaza strip. van den Berg MM, Madi HH, Khader A, et al. PLoS One. 2015;10:0. [PMC free article] [PubMed] [Google Scholar]

Effect of hypertensive disorders of pregnancy on maternal health outcomes at primary health care centers in Gaza strip - Palestine. Khalil Jamil Elqatrawi AY. J Adv Med Med Res. 2019:1–11. [Google Scholar]

The role of laboratory medicine for health during pregnancy. Alkhatib A. http://jscc-jp.gr.jp/home/wp-content/uploads/2018/12/ejifcc2018vol29no4.pdf#page=43. EJIFCC. 2018;29:280–284. [PMC free article] [PubMed] [Google Scholar]

Changes in the blood volume during pregnancy and delivery. Pritchard JA. Anesthesiology. 1965;26:393–399. [PubMed] [Google Scholar]

Physiological changes in pregnancy. Soma-Pillay P, Nelson-Piercy C, Tolppanen H, Mebazaa A. Cardiovasc J Afr. 2016;27:89–94. [PMC free article] [PubMed] [Google Scholar]

Emerging understanding and measurement of plasma volume expansion in pregnancy. Vricella LK. Am J Clin Nutr. 2017;106:1620–1625. [PMC free article] [PubMed] [Google Scholar]

Management of iron deficiency anemia in pregnancy in India. Tandon R, Jain A, Malhotra P. Indian J Hematol Blood Transfus. 2018;34:204–215. [PMC free article] [PubMed] [Google Scholar]

Anemia associated with pregnancy. Morrison J, Parrish M. Glob Libr Women's Med. :2016. [Google Scholar]

High and low hemoglobin levels during pregnancy: differential risks for preterm birth and small for gestational age. Scanlon KS, Yip R, Schieve LA, Cogswell ME. Obstet Gynecol. 2000;96:741–748. [PubMed] [Google Scholar]

Hemoglobin levels during the first trimester of pregnancy are associated with the risk of gestational diabetes mellitus, pre-eclampsia and preterm birth in Chinese women: a retrospective study. Wang C, Lin L, Su R, et al. BMC Pregnancy Childbirth. 2018;18:263. [PMC free article] [PubMed] [Google Scholar]

Comparison of gestational diabetes mellitus and pre-eclampsia in women with high hemoglobin in the first trimester of pregnancy: a longitudinal study. Mehrabian F, Hosseini SM. Pak J Med Sci. 2013;29:986–990. [PMC free article] [PubMed] [Google Scholar]

Maternal hemoglobin and risk of gestational diabetes mellitus in Chinese women. Lao TT, Chan LY, Tam KF, Ho LF. Obstet Gynecol. 2002;99:807–812. [PubMed] [Google Scholar]

High maternal hemoglobin and ferritin values as risk factors for gestational diabetes. Tarim E, Kilicdag E, Bagis T, Ergin T. Int J Gynaecol Obstet. 2004;84:259–261. [PubMed] [Google Scholar]

High and low haemoglobin levels in early pregnancy are associated to a higher risk of miscarriage: a population-based cohort study. Díaz-López A, Ribot B, Basora J, Arija V. Nutrients. 2021;13:1578. [PMC free article] [PubMed] [Google Scholar]

U-shaped curve for risk associated with maternal hemoglobin, iron status, or iron supplementation. Dewey KG, Oaks BM. Am J Clin Nutr. 2017;106:1694–1702. [PMC free article] [PubMed] [Google Scholar]

Maternal hemoglobin concentration during pregnancy and risk of stillbirth. Stephansson O, Dickman PW, Johansson A, Cnattingius S. JAMA. 2000;284:2611–2617. [PubMed] [Google Scholar]

Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy. [ Oct; 2021 ];Rayis DA, Musa IR, Al-Shafei AI, Moheldein AH, El-Gendy OA, Adam I. https://apps.who.int/iris/bitstream/handle/10665/85975/WHO_NMH_MND_13.2_eng.pdf. J Obstet Gynaecol. 2013 :1–5.

Gestational diabetes mellitus diagnosed at 24 to 28 weeks of gestation in older and obese women: is it too late? Kim W, Park SK, Kim YL. PLoS One. 2019;14:0. [PMC free article] [PubMed] [Google Scholar]

Iron and insulin resistance. Fargion S, Dongiovanni P, Guzzo A, Colombo S, Valenti L, Fracanzani AL. Aliment Pharmacol Ther. 2005;22 Suppl 2:61–63. [PubMed] [Google Scholar]

Gestational diabetes: pathogenesis and consequences to mother and offspring. Kaaja R, Rönnemaa T. Rev Diabet Stud. 2008;5:194–202. [PMC free article] [PubMed] [Google Scholar]

Effects of hemoglobin levels during pregnancy on adverse maternal and infant outcomes: a systematic review and meta-analysis. Jung J, Rahman MM, Rahman MS, Swe KT, Islam MR, Rahman MO, Akter S. Ann N Y Acad Sci. 2019;1450:69–82. [PubMed] [Google Scholar]

Hemoglobin level is positively associated with blood pressure in a large cohort of healthy individuals. Atsma F, Veldhuizen I, de Kort W, van Kraaij M, Pasker-de Jong P, Deinum J. Hypertension. 2012;60:936–941. [PubMed] [Google Scholar]

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Published

2022-12-20

How to Cite

Bektemirova , Z. 2022. The association between high hemoglobin levels and pregnancy complications, gestational diabetes and hypertension. Preventive Medicine and Health. 1, 1 (Dec. 2022), 64–71. DOI:https://doi.org/10.47689/2181-3663-vol1-iss1-pp64-71.