Характеристика иммунного профиля при раневой инфекции у больных на фоне сахарного диабета

Бахтиёр  Хамдамов; Азиз  Дехконов; Алишержон  Хамдамов; Малика  Тураева

doi:10.47689/2181-3663-vol3-iss4-pp9-18

Bakhtiyor Khamdamov DSc, Professor, Bukhara State Medical Institute
Aziz Dekhonov Purulent surgeon, Bukhara regional multidisciplinary medical center
Alisherjon Khamdamov Assistant, Bukhara State Medical Institute
Malika Turayeva Assistant, Bukhara State Medical Institute

DOI

https://doi.org/10.47689/2181-3663-vol3-iss4-pp9-18

Keywords

immune profile , wound infection , diabetes mellitus

Abstract

Comparative characteristics of the parameters of the immune system of T- and B-lymphocytes showed the presence of an imbalance and tension in the immune system of patients with wound infection on the background of diabetes mellitus, which indicates the development of a systemic inflammatory reaction syndrome and the occurrence of gross immunological rearrangements reflected in the significant activity of lymphocytes with markers of early activation (CD25+ cells) and the readiness of cells to apoptosis (CD95+ cells), as well as natural killers (CD16+ cells). In patients with wound infection on the background of DM, in comparison with healthy people, it was shown that the content of all studied immunocompetent cells was significantly increased. This fact indicates that all lymphocytes are activated and the immune system is tense, which is associated with a sufficiently high number of pathogens in the focus and the development of systemic inflammatory reaction syndrome (SIRS) in patients, which in our opinion aggravates the course of the wound process.

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Published

2024-08-15

How to Cite

Khamdamov , B. , Dekhonov , A. , Khamdamov , A. and Turayeva, M. 2024. Characteristics of the immune profile in wound infection in patients with diabetes mellitus. Preventive Medicine and Health. 3, 4 (Aug. 2024), 9–18. DOI:https://doi.org/10.47689/2181-3663-vol3-iss4-pp9-18.