The importance of biochemical markers in predicting pregnancy outcomes and extending gestation in cases of PPROM

Preterm premature rupture of membranes (PPROM) represents a critical obstetric condition, significantly elevating the risks of preterm birth, neonatal complications, and maternal infections. Identifying pregnancies susceptible to PPROM at an early stage is vital for enhancing perinatal outcomes. Several biochemical markers, such as fetal fibronectin (fFN), placental alpha-microglobulin-1 (PAMG-1), insulin-like growth factor binding protein-1 (IGFBP-1), and inflammatory markers like           C-reactive protein (CRP) and interleukins, demonstrate considerable diagnostic and predictive significance. This study examines the role of these biomarkers in PPROM diagnosis, prognosis of pregnancy outcomes, and the formulation of clinical interventions. Integrating biomarker analysis into obstetric care enables timely administration of corticosteroids, antibiotics, and tocolytics, thereby prolonging gestation and improving neonatal survival. Further research is required to optimize biomarker-based strategies for personalized patient management.