DOI
https://doi.org/10.47689/2181-3663-vol4-iss3-pp264-269Keywords
cerebrovascular diseases , kidney morphology , glomerulosclerosis , microcirculation , endothelial dysfunction , nephrocirculatory syndrome , arterial hypertensionAbstract
This article analyzes the pathomorphological changes observed in kidney tissues in relation to the course of cerebrovascular diseases in patients aged 35-45. Conditions involving cerebral circulation disorders, including pathologies associated with stroke, discirculatory encephalopathy, and arterial hypertension, cause complex morphological and histopathological changes in the nephrocirculatory system. The study elucidates the pathogenesis of glomerular sclerosis, tubulointerstitial dystrophies, endothelial dysfunction, and microcirculatory changes, as well as their correlation with clinical and biochemical indicators.
References
Сахаров В.А., Кузнецова Е.Н. Морфологические изменения почек при сосудистых заболеваниях мозга. – Неврологический журнал, 2020. – №5(25). – С. 47–53. DOI: 10.17816/NJ2020-5-47-53.
Oparil S., Schmieder R.E. New insights into the kidney–brain connection in hypertension. Nature Reviews Nephrology, 2021. – Vol. 17(5). – P. 319–333. DOI: 10.1038/s41581-021-00411-1.
Иваницкий А.М., Лебедев В.П. Патогенетическая взаимосвязь почечной и мозговой ишемии. – Патологическая физиология и экспериментальная терапия, 2019. – №3(63). – С. 25–34.
Suzuki K., Matsushita K. Cerebro-renal interaction: microvascular damage and endothelial dysfunction. Clinical Nephrology, 2020. – Vol. 93(1). – P. 1–10. DOI: 10.5414/CN109870.
Жуков А.В., Киселёв С.В. Эндотелиальная дисфункция при гипертонической энцефалопатии и поражении почек. – Архив патологии, 2021. – Т. 83. – №4. – С. 61–68.
Wang X., Gao L., Li J. Oxidative stress and mitochondrial dysfunction in the brain–kidney axis. Frontiers in Physiology, 2022. – Vol. 13. – Article 1027145. DOI: 10.3389/fphys.2022.1027145.
Калинина Е.Н., Хачатурян А.Г., Смирнов П.В. Гистологические особенности почек при сосудистых заболеваниях. – Морфология, 2020. – Т. 158. – №2. – С. 82–89.
Sarnak M.J., Tighiouart H., Scott T.M. Chronic kidney disease and cerebrovascular disease: shared mechanisms and risk factors. Stroke, 2019. – Vol. 50(2). – P. 457–466. DOI: 10.1161/STROKEAHA.118.023445.
Григорьев В.А., Гладков А.А. Патофизиологические основы нефрососудистого синдрома при инсультах. – Клиническая медицина, 2021. – №10(99). – С. 15–22.
Gao Y., Zhang J., Xu Z. Microvascular crosstalk between kidney and brain: potential therapeutic targets. Journal of Translational Medicine, 2023. – Vol. 21(2). – P. 187–195. DOI: 10.1186/s12967-023-04014-6.
Downloads
18 8Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Нодирбек Абдуллаев, Сардорбек Мамадалиев, Иброхим Мирабдуллаев
This work is licensed under a Creative Commons Attribution 4.0 International License.
