Homiladorlikni turli asoratlari va nuqsonli xomila rivojlanishining profilaktikasida predgravidar tayyorgarlikni optimallashtirish

  • Magistrant, 1-sonli akusherlik va ginekologiya kafedrasi, Andijon davlat tibbiyot instituti
  • Assistent, 1-sonli akusherlik va ginekologiya kafedrasi, Andijon davlat tibbiyot instituti

DOI

https://doi.org/10.47689/2181-3663-vol3-iss2-pp16-22

Kalit so‘zlar

nuqsonli homila , asoratli homiladorlik , gomosistein , predgravidar tayyorgarlik

Annotasiya

Zamonaviy tibbiyotning rivojlanishi bilan asoratlarning oldini olish imkoniyati kengaymoqda, ammo hamon homiladorlikni rejalashtirishga yetarlicha e’tibor berilmayapti. Bu esa onalar va bolalar o’rtasida o’lim va kasallanish ko’rsarkichlarininhg yuqori bo’lishiga sabab bo’lmoqda.Shuning uchun  qiz bolaning tug’ilganidan 18 yoshgacha bo’lgan reproduktiv tizimini himoya qilish, sog’lom avlod tugilishi va millatning demografik salohiyatini yuksaltirish uchun kelajakda onalikka predgravidar tayyorgarlik jarayonlarini optimallashtirish bugungi kunda dolzarb masalalardan biridir.

Bibliografik manbalar

Savage D.G., Lindenbaum J., Stabler S.P., Allen R.H. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med. 1994; 96: 239–246.

Klee G.G. Cobalamin and folate evaluation; measurement of methylmalonic acid and homocysteine vs vitamin B12 and folate. Clin Chem. 2000; 46: 1277–1283.

Refsum H., Ueland P.M., Nygård O., Vollset S.E. Homocysteine and cardiovascular disease. Ann Rev Med. 1998; 49: 31–62.

Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002; 288: 2015–2022.

Ray J.G., Laskin C.A. Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review. Placenta. 1999; 20: 519–529.

Vollset S.E., Refsum H., Irgens L.M., Emblem B.M., Tverdal A., Gjessing H.K. Plasma total homocysteine, pregnancy complications, and adverse outcomes: the Hordaland Homocysteine Study. Am J Clin Nutr. 2000; 71: 962–968.

Nilsson K., Gustafson L., Faldt R., Andersson A., Brattstrom L., Lindgren A. Hyperhomocysteinaemia – a common finding in a psychogeriatric population. Eur J Clin Invest. 1996; 26: 853–859.

Smith A.D. Homocysteine, B vitamins, and cognitive deficit in the elderly [Editorial]. Am J Clin Nutr. 2002; 75: 785–786.

Зобова Д.А., Козлов С.А. Роль гомоцистеина в патогенезе некоторых заболеваний. Известия вузов. Поволжский регион. Медицинские науки. 2016; 3 (39).

Rasmussen K., Møller J. Total homocysteine determination in clinical practice. Ann Clin Biochem. 2000; 37: 627–648.

Ubbink J.B. Assay methods for the measurement of total homocyst(e)ine in plasma. Semin Thromb Hemost. 2000; 26: 233–241.

Степанова М.С., Булыгина Е.Р., Болдырев А.А. Карнозин защищает мозг в условиях окислительного стресса, создаваемого в период пренатального развития. Журнал акушерства и женских болезней. 2010; LIX (4): 81–89.

Jakubowski H. Synthesis of homocysteine thiolactone in normal and malignant cells. In: Graham I., Refsum H., Rosenberg I.H., Ueland P.M., eds. Homocysteine Metabolism: From Basic Science to Clinical Medicine. Boston: Kluwer Academic Publishers; 1997: 157–165.

Dudman N.P., Hicks C., Lynch J.F., Wilcken D.E., Wang J. Homocysteine thiolactone disposal by human arterial endothelial cells and serum in vitro. Arterioscler Thromb. 1991; 11: 663–670.

Mudd S.H., Matorin A.I., Levy H.L. Homocysteine thiolactone: failure to detect in human serum or plasma. Res Commun Chem Pathol Pharmacol. 1989; 63: 297–300.

Ubbink J.B., Vermaak W.J.H., van der Merwe A., Becker P.J. The effect of blood sample aging and food consumption on plasma total homocysteine levels. Clin Chim Acta. 1992; 207: 119–128.

Guttormsen A.B., Schneede J., Fiskerstrand T., Ueland P.M., Refsum H. Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy subjects. J Nutr. 1994; 124: 1934–1941.

Nurk E., Tell G.S., Nygard O., Refsum H., Ueland P.M., Vollset S.E. Plasma total homocysteine is influenced by prandial status in humans: the Hordaland Homocysteine Study. J Nutr. 2001; 131: 1214–1216.

Маслов А.П., Баженов Л.Н., Гетман З.В., Рыжкова Н.В. Исследование плейотропного эффекта аторвастатина по влиянию на уровень гомоцистеинемии у больных, перенесших инфаркт миокарда. Медицина в Кузбассе. 2014; S3: 67–71.

Langman L.J., Cole D.E. Homocysteine: cholesterol of the 90s? Clin Chim Acta. 1999; 286: 63–80.

Andersson A., Isaksson A., Brattstrom L., Hultberg B. Homocysteine and other thiols determined in plasma by HPLC and thiol-specific postcolumn derivatization. Clin Chem. 1993; 39: 1590–1597.

World Health Organization [WHO] 2023

.American College of Obstetricians and Gynecologists (ACOG)

The Lancet

Centers for Disease Control and Prevention (CDC)

European Society of Human Reproduction and Embryology (ESHRE)

Chandra, S., Tripathi, A. K., Mishra, S., Vaish, A. K., et al. "Hyperhomocysteinemia and its correlation with pregnancy-induced hypertension and eclampsia." Journal of Obstetrics and Gynaecology of India, 2009.

Ray, J. G., et al. "Meta-analysis of hyperhomocysteinemia as a risk factor for venous thromboembolism." European Journal of Obstetrics & Gynecology, 2007.

Malinow, M. R., et al. "Homocysteine, diet, and cardiovascular diseases." Atherosclerosis, 1999.

Gong, X., et al. "Serum homocysteine and folate concentrations in early pregnancy and subsequent adverse outcomes." BMC Pregnancy and Childbirth, 2023.

Anand, S., et al. "The association between serum homocysteine levels and placenta-mediated complications." Cureus, 2023.

. Journal of Obstetrics and Gynaecology

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Homiladorlikni turli asoratlari va nuqsonli xomila rivojlanishining profilaktikasida predgravidar tayyorgarlikni  optimallashtirish

Qanday qilib iqtibos keltirish kerak

Soliyeva , Z. and Nazirova , Z. 2024. Homiladorlikni turli asoratlari va nuqsonli xomila rivojlanishining profilaktikasida predgravidar tayyorgarlikni optimallashtirish. Profilaktik tibbiyot va salomlatlik. 3, 2 (Apr. 2024), 16–22. DOI:https://doi.org/10.47689/2181-3663-vol3-iss2-pp16-22.