Шикастланишдан кейинги риносинуситда бурун шиллиқ қаватининг гистокимёвий хусусиятлари

Кахрамонжон Юлдашев; Носиржон Маҳкамов

doi:10.47689/2181-3663-vol4-iss1-pp57-65

Kakhramonjon Yuldashev Assistant, Fergana State Medical Institute
Nosirjon Makhkamov Doctor of Medical Sciences, Professor, Andijan State Medical Institute

DOI

https://doi.org/10.47689/2181-3663-vol4-iss1-pp57-65

Keywords

histochemical study , nasal mucosa , PAS-positive structures , Van Gieson staining

Abstract

In chronic post-traumatic rhinosinusitis following nasal septum injury, the nasal mucosa demonstrates hypoaeration and airway deformation. Prolonged chronic hypoxia leads to enhanced fibroblast proliferation within the mucosal stroma, accompanied by accumulation of acidic mucopolysaccharides. This process results in retention of viscous mucinous secretions, as well as mucoid and fibrinoid swelling of the mucosa. Such changes contribute to increased levels of acidic mucopolysaccharides, disruption of histoarchitectonics, and disorganization of fibrous structures, with the formation of irregularly arranged coarse collagen fibers. Moreover, the abundance of PAS-positive structures was shown to correlate with excessive accumulation of acidic mucopolysaccharides and an increase in coarse fuchsinophilic fibers within the nasal mucosa.

References

Fokkens WJ, Lund VJ, Hopkins C, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology 58(Suppl S29): 1–464, 2020.

Orlandi RR, Kingdom TT, Smith TL, et al. International Consensus Statement on Allergy and Rhinology: Rhinosinusitis 2021. Int Forum Allergy Rhinol 11(3): 213–739, 2021.

Giacomelli F, Barillari MR, Gioacchini FM, et al. Structural changes of nasal mucosa in chronic rhinosinusitis: a systematic review. Laryngoscope Investig Otolaryngol 5(6): 1162–1170, 2020.

Wagner Mackenzie B, Bassiouni A, Vreugde S, Wormald P-J. Remodeling in chronic rhinosinusitis: mechanisms and clinical implications. J Clin Med 10(8): 1609 (1–18), 2021.

Zhang Y, Wang C, Han D, Bachert C. Roles of hypoxia and HIF-1α in chronic rhinosinusitis. Allergy 76(2): 554–565, 2021.

Kim DH, Park HY, Lee JG, et al. Mucin (MUC5AC) expression and goblet cell hyperplasia in chronic rhinosinusitis. Int Forum Allergy Rhinol 10(7): 845–853, 2020.

Shin HW, Cho K-S, Park I-H. Role of fibroblasts in chronic rhinosinusitis and nasal polyps. Clin Exp Otorhinolaryngol 16(2): 107–119, 2023.

Ong YK, Tan L, Leong JL, et al. Association between nasal septal deviation and chronic rhinosinusitis: a systematic review and meta-analysis. Am J Rhinol Allergy 36(6): 827–838, 2022.

Workman AD, Cohen NA. The role of mucins in chronic rhinosinusitis. Curr Allergy Asthma Rep 21(1): 1–9, 2021.

Lee CF, Chen TA, Lin C, et al. Effect of septoplasty on nasal mucociliary clearance in patients with septal deviation. Clin Otolaryngol 45(5): 738–744, 2020.

Ural A, Okur E, Akif Kizilay C, et al. Impact of septoplasty on chronic rhinosinusitis symptoms and mucociliary function. Eur Arch Otorhinolaryngol 277(8): 2303–2309, 2020.

Wang M, Zhang L, Zhang Y, et al. Fibrosis and extracellular matrix remodeling in chronic rhinosinusitis with nasal polyps: updates and therapeutic perspectives. Front Pharmacol 13: 876543 (1–14), 2022.

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Published

2025-07-15

How to Cite

Yuldashev , K. and Makhkamov , N. 2025. Histochemical characteristics of the nasal mucosa in post-traumatic rhinosinusitis. Preventive Medicine and Health. 4, 1 (Jul. 2025), 57–65. DOI:https://doi.org/10.47689/2181-3663-vol4-iss1-pp57-65.