Pathogenetic role of endogenous intoxication in chronic tubulointerstitial nephritis in children

Ablokul Akhmatov

doi:10.47689/2181-3663-vol4-iss4-pp237-244

Ablokul Akhmatov Candidate of Medical Sciences, Associate Professor, Department of 2-Pediatrics, Samarkand State Medical University

DOI

https://doi.org/10.47689/2181-3663-vol4-iss4-pp237-244

Keywords

chronic tubulointerstitial nephritis , endogenous intoxication , children , protein metabolism , renal pathology , pathogenesis

Abstract

The study examines the pathogenetic role of endogenous intoxication in the development and progression of chronic tubulointerstitial nephritis (CTIN) in children. Based on the analysis of clinical and biochemical parameters in 120 pediatric patients aged 4-15 years, the research identifies the relationship between protein metabolism disturbances and the intensity of endogenous intoxication. The results indicate that both latent and recurrent forms of CTIN are associated with increased levels of medium-molecular toxins, which play a significant role in renal tissue damage, inflammation, and metabolic imbalance. The findings contribute to a deeper understanding of the mechanisms of CTIN pathogenesis and may serve as a basis for improving diagnostic and therapeutic approaches in pediatric nephrology.

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Published

2025-10-20

How to Cite

Akhmatov, A. 2025. Pathogenetic role of endogenous intoxication in chronic tubulointerstitial nephritis in children. Preventive Medicine and Health. 4, 4 (Oct. 2025), 237–244. DOI:https://doi.org/10.47689/2181-3663-vol4-iss4-pp237-244.