DOI
https://doi.org/10.47689/2181-3663-vol4-iss4-pp237-244Kalit so‘zlar
surunkali tubulointerstitsial nefrit , endogen intoksikatsiya , bolalar , oqsil almashinuvi , buyrak patologiyasi , patogenezAnnotasiya
Mazkur tadqiqot bolalarda uchraydigan surunkali tubulointerstitsial nefrit (STIN) rivojlanishida endogen intoksikatsiyaning patogenetik rolini o‘rganishga bag‘ishlangan. 4-15 yoshdagi 120 nafar bemorlarning klinik va biokimyoviy ko‘rsatkichlari tahlili asosida oqsil almashinuvi buzilishlari bilan endogen intoksikatsiya darajasi o‘rtasidagi bog‘liqlik aniqlangan. Tadqiqot natijalari STINning yashirin va qaytalanuvchi shakllarida o‘rtacha molekulali toksinlar miqdorining oshishi buyrak to‘qimalarining shikastlanishida, yallig‘lanish va metabolik muvozanat buzilishida muhim omil ekanini ko‘rsatdi. Olingan ma’lumotlar bolalar nefrologiyasida STIN patogenezining mexanizmlarini chuqurroq anglash va tashxis hamda davolash usullarini takomillashtirishga xizmat qiladi.
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