DOI
https://doi.org/10.47689/2181-3663-vol4-iss5-pp51-56Keywords
lipid profile , coagulation profile , brain-derived neurotrophic factor (BDNF) , cortical vascular dementia , subcortical vascular dementiaAbstract
Vascular dementia encompasses a set of clinical-pathomorphological and clinical-pathogenetic syndromes, characterized by the interrelation between cerebrovascular disorders and cognitive impairments. This study aimed to investigate pathophysiological blood changes in individuals with vascular dementia, specifically alterations in brain-derived neurotrophic factor (BDNF) levels in the blood serum of patients with cortical and subcortical forms of vascular dementia. BDNF plays a crucial role in ontogenesis and is one of the central components in adult brain functioning. It contributes to neuronal viability and metabolism, neurogenesis, modulation of dendritic branching and morphology, and provides a protective effect against neuronal degeneration and inflammation, helping to prevent neuronal apoptosis. The article discusses the potential use of BDNF as an immunobiochemical marker for diagnosing vascular dementia.
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