DOI
https://doi.org/10.47689/2181-3663-vol3-iss5-pp82-88Kalit so‘zlar
SOOʻK , tizimli yallig‘lanish , oksidlanish stressi , nafas yo‘llarining obstruktsiyasi , o‘pka gipertenziyasi , yallig‘lanish mediatoriAnnotasiya
Surunkali obstruktiv o‘pka kasalligi (SOOʻK) — bu nafas olish tizimining yomonlashuvchi kasalligi bo‘lib, doimiy havo oqimining cheklanishi va o‘pka yallig‘lanishining kuchayishi bilan ajralib turadi. Tizimli yallig‘lanish SOOʻK patogenezida muhim rol o‘ynaydi, kasallikning rivojlanishi va hamroh kasalliklarning paydo bo‘lishiga ta’sir ko‘rsatadi. Ushbu sharhda SOOʻKda yallig‘lanish tufayli yuzaga keladigan patologik o‘zgarishlarning ketma-ket bosqichlari, dastlabki nafas yo‘llari o‘zgarishlaridan tortib, rivojlangan tizimli ta’sirlargacha o‘rganiladi. Kasallik jarayoni uzoq muddatli xavf faktorlariga, masalan, chekish, havoning ifloslanishi va kasbiy xavflarga duchor bo‘lishdan boshlanadi. Bu shilliq qavatning sekretsiyasining oshishiga va manzarali epiteliya hujayralarining disfunktsiyasiga olib keladi, natijada mukotsilyar tozalashning buzilishi va infeksiyalarga nisbatan sezgirlikning oshishi kuzatiladi. Yallig‘lanish davom etgan sari, bronxial obstruktsiya va nafas yo‘llarining remodellashtirilishi yuzaga keladi, bu esa havo oqimini cheklaydi. O‘pkaning giperinflyatsiyasi va emfizema nafas olish yetishmovchiligini yanada kuchaytiradi, elastik tiklanishni kamaytiradi va nafas olish ishini oshiradi. Kelajakdagi tadqiqotlar aniq tibbiyot yondoshuvlari, biomarkerni aniqlash va yangi yallig‘lanishga qarshi davolash usullarini ishlab chiqishga e’tibor qaratishi kerak, bu kasallikning rivojlanishini sekinlashtirish va bemorlarning natijalarini yaxshilashga yordam beradi.
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